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师资队伍
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兼职与客座教授
 
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黄宝玉,男,1987年6月出生,理学博士,副教授

研究方向

贝类天然免疫防御机制。近几年主持国家自然科学基金青年项目、中国博士后科学基金面上项目、山东省博士后创新项目资助等国家及省级课题。发表SCI论文23篇,其中以第一作者发表8篇。申请并获授权国家发明专利一项。

教育经历

2006-09至2010-07 山东大学 生物技术专业 理学学士

2010-09至2015-07 中国科学院海洋研究所 海洋生物专业 理学博士

工作经历:

2015-07至2018-07  中国科学院海洋研究所 博士后

2018-07至2019-07  中国科学院海洋研究所 助理研究员

2019-07至今     beat365唯一官网 讲师

正在承担及主持完成的项目

1.国家自然科学基金青年项目:长牡蛎干扰素调节因子免疫功能及作用机制研究(31802328);2019.01- 2021.12;26万元(主持,在研);

2.中国博士后科学基金面上资助:长牡蛎IRF抗病毒转录调控机制的研究(2016M592258);2016.05- 2018.07;5万元(主持,已结题);

3.山东省博士后创新项目资助:长牡蛎Rel/NF-κB的免疫功能,调控蛋白及其可变剪切的研究;2016.09- 2018.07;3万元(主持,已结题)

发表论文(23篇,其中以第一作者发表SCI论文8篇):

1. Huang Baoyu, Tang Xueying, Zhang Linlin, Li Li, Wang Wei, Liu Mingkun, Zhang Guofan. IKKε-like plays an important role in the innate immune signaling of the Pacific oyster (Crassostrea gigas), Fish & Shellfish Immunology 2019; 93: 551-558. SCI,中科院一区TOP期刊)

2. Huang Baoyu, Zhang Linlin, Du Yishuai, Li Li, Tang Xueying, Zhang Guofan. Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster. Fish & Shellfish Immunology. 2016; 48: 12-19. SCI,中科院一区TOP期刊)

3. Huang Baoyu, Zhang Linlin, Li Li, Tang Xueying, Zhang Guofan. Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas. Fish & Shellfish Immunology. 2015; 43: 485-490.SCI,中科院一区TOP期刊)

4. Huang Baoyu, Zhang Linlin, Tang Xueying, Zhang Guofan, Li Li. Genome-Wide Analysis of Alternative Splicing Provides Insights into Stress Adaptation of the Pacific Oyster. Marine Biotechnology. 2016; 18: 598-609. SCI,中科院一区TOP期刊)

5. Huang Baoyu, Zhang Linlin, Xu Fei, Tang Xueying, Li Li, Wang Wei, Liu Mingkun, Zhang Guofan. Oyster Versatile IKKα/βs Are Involved in Toll-Like Receptor and RIG-I-Like Receptor Signaling for Innate Immune Response. Frontiers in Immunology. 2019; 10:1826. SCIIF4.716

6. Huang Baoyu, Zhang Linlin, Du Yishuai, Xu Fei, Li Li, Zhang Guofan. Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates. Scientific Reports. 2017; 7: 8217. SCIIF4.122

7. Huang Baoyu, Meng Jie, Yang Mei, Xu Fei, Li Xinzheng, Li Li, et al. Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus. Developmental and Comparative Immunology. 2017; 71: 82-87. SCIIF2.913

8. Huang Baoyu, Zhang Linlin, Du Yishuai, Li Li, Qu Tao, Meng Jie, et al. Alternative splicing and immune response of Crassostrea gigas tumor necrosis factor receptor-associated factor 3. Molecular Biology Reports. 2014; 41: 6481-6491.SCIIF1.889

9. Tang Xueying, Huang Baoyu, Zhang Linlin, Li Li, Zhang Guofan. TANK-binding kinase-1 broadly affects oyster immune response to bacteria and viruses. Fish & Shellfish Immunology. 2016; 56: 330-335.

10. Tang Xueying, Huang Baoyu, Zhang Linlin, Li Li, Zhang Guofan. Molecular characterization of Pacific oyster (Crassostrea gigas) IRAK4 gene and its role in MyD88-dependent pathway. Developmental and Comparative Immunology. 2017; 72: 21-29.

11. Qu Tao, Huang Baoyu, Zhang Linlin, Li Li, Xu Fei, Huang Wen, et al. Identification and Functional Characterization of Two Executioner Caspases in Crassostrea gigas. PLoS ONE. 2014; 9: e89040.

12. Song Kai, Li Yingxiang, Huang Baoyu, Li Li, Zhang Guofan. Genetic and evolutionary patterns of innate immune genes in the Pacific oyster Crassostrea gigas. Developmental and Comparative Immunology. 2017; 77: 17-22.

13. Ji Peng, Xu Fei, Huang Baoyu, Li Yingxiang, Li Li, Zhang Guofan. Molecular Characterization and Functional Analysis of a Putative Octopamine/Tyramine Receptor during the Developmental Stages of the Pacific Oyster, Crassostrea gigas. PLoS ONE. 2016; 11: e0168574.

14. Liu Youli, Li Li, Huang Baoyu, Wang Wei, Zhang Guofan. RNAi based transcriptome suggests genes potentially regulated by HSF1 in the Pacific oyster Crassostrea gigas under thermal stress. BMC Genomics. 2019; 20: 639.

15. Li Chunyan, Qu Tao, Huang Baoyu, Ji Peng, Huang Wen, Que Huayong, et al. Cloning and characterization of a novel caspase-8-like gene in Crassostrea gigas. Fish & Shellfish Immunology. 2015; 46: 486-492.

16. Du Yishuai, Zhang Linlin, Huang Baoyu, Guan Xudong, Li Li, Zhang Guofan. Molecular Cloning, Characterization, and Expression of Two Myeloid Differentiation Factor 88 (Myd88) in Pacific Oyster, Crassostrea gigas. Jounal of World Aquaculture Society. 2013; 44: 759-774.

17. Meng Jie, Zhang Linlin, Huang Baoyu, Li Li, Zhang Guofan. Comparative analysis of oyster (Crassostrea gigas) immune responses under challenge by different Vibrio strains and conditions. Molluscan Research. 2014: 1-11.

18. Du Yishuai, Zhang Linlin, Xu Fei, Huang Baoyu, Zhang Guofan, Li Li. Validation of housekeeping genes as internal controls for studying gene expression during Pacific oyster (Crassostrea gigas) development by quantitative real-time PCR. Fish & Shellfish Immunology. 2013; 34: 939-45.

19. Qu Tao, Zhang Linlin, Wang Wei, Huang Baoyu, Li Yingxiang, Zhu Qihui, et al. Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense. Developmental and Comparative Immunology. 2015; 51: 74-8.

20. Liu Sheng, Li Li, Meng Jie, Song Kai, Huang Baoyu, Wang Wei, Zhang Guofan, Association and Functional Analyses Revealed That PPP1R3B Plays an Important Role in the Regulation of Glycogen Content in the Pacific Oyster Crassostrea gigas. Frontiers in Genetics. 2019; 10:106.

21. Meng Jie, Zhu Qihui, Zhang Linlin, Li Chunyan, Li Li, She Zhicai, Huang Baoyu, Zhang Guofan. Genome and transcriptome analyses provide insight into the euryhaline adaptation mechanism of Crassostrea gigas. PLoS ONE. 2013; 8: e58563.

22. Li Li, Li Ao, Song Kai, Meng Jie, Guo Ximing, Li Shiming, et al. Divergence and plasticity shape adaptive potential of the Pacific oyster. Nature Ecology & Evolution. 2018. (作者中有署名)

23. Zhang Guofan, Fang Xiaodong, Guo Ximing, Li Li, Luo Ruibang, Xu Fei, et al. The oyster genome reveals stress adaptation and complexity of shell formation. Nature. 2012; 490: 49-54. (作者中有署名)

申请专利:

长牡蛎Poly(I:C)应激实验荧光定量的内参基因及其引物和应用,专利号:ZL201410257711.7 (第一位,已授权)。

 
 

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